Bio Medical Engineering – Final Projects

Bio Medical Engineering – Final Projects

Projects are related to Bio-informatics, medical image processing, bio medical instrumentation, system identification, biometrics, physiological signal processing, bio mechanics, bio materials and systems analysis & 3-D modeling etc.

Platform: C, C++, MATLAB, JAVA, LabView

List of projects

1. Smoothing Of An Electrocardiogram (ECG) Noisy Signal By a FIR Filter.

2. Blood Glucose Model


Professor Jonathan Butcher and Jack Thompson projects:
1). Optimization of gene delivery for cardiovascular applications.
The best way to understand biological phenomena is through conducting gain and loss of function
experiments. Achieving these experiments requires the ability to add DNA into cells to increase
expression of a protein, or to add interfering RNA to reduce (knock-down) expression of the protein. We
collaborate with a molecular biologist that has made several novel DNA plasmids to enhance the
expression of proteins important in valve disease. The objective of this project is to optimize the delivery
of these plasmids into live cells. We will explore electroporation, virus, and chemical based methods in
both adult, embryonic, and stem cell sources. We will test the effects of gaining and losing this protein at
embryonic and adult stages, and the potential effects of mechanical stimulation. Students working on this
project will gain valuable expertise in molecular biology, plasmid purification, and cloning. A
background in cell biology, molecular biology or biochemistry is helpful in this project.
Contact information:
2). Design of an ex vivo/in vivo bioreactor for cardiovascular implants
Typical bioreactors for tissue engineered cardiovascular tissues simulate in vivo mechanical conditions on
a bench. These are often bulky devices with expensive control systems to replicate internal environments,
and are not capable of using actual blood as the fluid medium. Our goal in this project is to design a
bioreactor system that itself could be implanted in a body cavity and condition a tissue prior to its
eventual use in its intended position. This innovation would remove much of the time and cost associated
with current approaches, but has significant design challenges. Students will explore the role of
immune/inflammatory response to biomaterials, and depending on project progression build a prototype
using 3D printing technology. Interested students should have experience in mechanical engineering
design, electrical engineering, and/or computer science. Some knowledge of biology is helpful but not
required. This project is best suited for a team of independently motivated students with minimallyoverlapping
skill sets.
Contact information:
3). BioHaptix 2013/2014 Project Proposal – Version 22 June 2013
Background: BioHaptix is currently engaged in the commercialization of a real-time soft tissue
characterization device that utilizes technology developed in Professor Jonathan Butcher’s Lab (see ). BioHaptix has identified a number of promising
applications including biomedical tissue research, in-vivo assessment of meat quality in cattle, and the
early assessment of preterm birth risk in pregnant women.
Opportunity: As with any early-stage business, there are a number of near term priorities for BioHaptix.
One of these involves the refinement and advancement of a prototype demonstrating the technology. This
prototype consists of 3 main elements:
1) Base Unit
2) PC Application
3) Probe
Materials and Methods: The main areas of refinement for each of the prototype elements are as follows:
1) Base Unit: Additional programming of the firmware loaded into the Arduino microcontroller to
improve robustness and increase automaticity. The
Arduino is at the heart of the Base Unit and controls
all other functions and subsystems within the Base
Unit and also communicates with the PC application
and Probe. An ideal candidate for this activity is
someone with a strong programming background
with specific experience in the creation of firmware
to control and direct hardware elements.
2) PC Application: Additional programming (Visual Basic 6 or VB6) to increase automaticity and
improve data post processing and visualization. An ideal candidate for this activity is someone with
strong VB6 background with some experience in parsing, summarizing, and analyzing large
amounts of data.
3) Probe: Mechanical and electrical updates to the functionalized electrode tip design to improve
ease of use and optimize it for use in the assessment of meat quality in live cattle. An ideal candidate
for this activity is someone with a solid mechanical design background with some experience in
basic electrical design (specifically flex circuits).
Criteria for Success: For each activity success would be defined as follows:
1) Base Unit:
a. Reduced overall test cycle time.
b. Demonstrated ability both receive inputs and send commands (switch electrode pairs) to the
c. Improvement management of subroutines associated with pressure controller an